B-cell lymphoma r gasquet

B cell lymphomas usually have genetic origins, though they are also linked to environmental factors, immunodeficiency, viruses, and connective tissue disorders. To put it bluntly, there is no truthful answer to, "What causes B cell lymphoma?" The "causes" are not entirely understood, so it is more helpful to focus on risk factors. Please see "What causes lymphoma?" for more detailed information. The major risk factors for NHL include Immune deficiencies These deficiencies can be genetic, drug-induced, linked to organ transplants, caused by chemical exposure, or be the result of other diseases such as HIV/AIDS. Autoimmune diseases The immune system constantly attacks a certain part of the body.

If cancer is suspected, the doctor will usually order blood tests. He will do a complete blood count (CBC) to discover the number of white blood cells, red blood cells, and platelets in your blood stream. Abnormal blood counts can be an indicator of lymphoma. The doctor will also check for other indicators, such as Lactate Dehydrogenase (LDH); high levels of LDH can indicate lymphoma.

The final step in diagnosis is a biopsy. The doctor will remove a small sample of lymph tissue, usually a portion of a lymph node or a whole lymph node, and send it to the lab for analysis. A biopsy will let the doctor know if you have cancer, what type it is, and it will help them stage the disease. Staging

Staging is an important step in diagnosing cancer. Once the doctor knows the type of cancer, they will need to determine the extent of the cancer’s metastasis, or spread throughout the body. This affects the type of treatment a patient needs. The stages of lymphoma are: Stage I In this stage, the tumor is restricted to one lymph group. For example, if the tumor has not spread beyond a cluster of lymph nodes in the neck, it is Stage I. Stage II In this stage, the lymphoma has spread and involves two lymph groups, which are on the same side (above or below) of the diaphragm. For example, if two lymph groups in the neck are involved, it is classified as Stage II. It is also possible for the lymphoma to affect one group of lymph nodes and a nearby organ in this stage, rather than two lymph groups. Stage III In this stage, the lymphoma is found on both sides of the diaphragm. One organ near the affected lymph groups may contain abnormal cells as well. Stage IV This is the most progressed stage of lymphoma and is marked by the involvement of more than one organ. Spread to the bone marrow, blood, and/or liver also indicates Stage 4 disease. Recurrent This stage of lymphoma indicates that the disease has come back after previous remission after treatment. Grades

Grades of cancer are also used. The designated grades are "A" and "B". Grade "A" cancer You have not suffered weight loss or experienced a high fever or night sweats. Grade "B" You have suffered weight loss and/or experienced a high fever or night sweats.

Treatment for B Cell Lymphoma differs based on the type of cancer and the staging. It also depends on how fast the cancer is growing and the patient’s age and medical history. A medical oncologist, hematologist, or radiation oncologist will treat the patient with the most aggressive and successful treatment that his or her body can handle. Follicular lymphoma treatments may include Chemotherapy This type of treatment is used on patients with indolent (slow-growing) cancers and aggressive cancers. High-dose chemotherapy is needed for very aggressive diseases. Radiation therapy This therapy is used for indolent lymphomas in the early stages (Stage I and II) and may be used for aggressive cancers of any stage. Radioimmunotherapy (radiolabeled monoclonal antibodies) Radioimmunotherapy combines monoclonal antibody therapy with radioactive isotopes. Though it was developed in the 1980’s, radioimmunotherapy is just now beginning to gain widespread acceptance. In the United States, it has been approved by the FDA for treatment of certain refractory and relapse NHL’s. The Zevalin® regimen has been approved by the FDA as a first-line radioummunotherapy treatment for certain follicular lymphoma patients. Stem Cell Transplantation This therapy is used for very aggressive cancers and for patients who have relapsed, or had a recurrence of a previously treated cancer. Watchful Waiting For indolent cancers that are diagnosed before symptoms present, doctors may carefully monitor patients without administering treatment. Chemotherapy or radiation will begin when symptoms present, thus making medical intervention necessary. Related Reading B cell Lymphoma Articles