Bioflavonoids – information; why it is recommended o gastroenterologista cuida do que

Bioflavonoids are a special class of plant polyphenolic compounds. Being found in high concentrations in many fruits, they are responsible for much of the coloring in such things as grapes, blueberries, and cherries. They are also found in fairly high concentrations in citrus fruits as well. Historically, Bioflavonoids were first described as "vitamin P" due to their ability to reduce capillary permeability. Since then their status as a vitamin has been dropped, but the research and use of various bioflavonoids has only increased. Some important bioflavonoids include quercetin, rutin, hesperidin, and the OPCs found in grapes, bilberries, and pine bark extractions to name a few. Source

Hesperidin is found primarily in the rinds of lemon and sweet oranges (Citrus sinensis). It is not all that commonly used as a supplement ingredient, but is still used in combination with vitamin C products or combined with ingredients as a synergist for a variety of conditions. Function; Why it is Recommended

Rutin is a flavonoid glycoside with quercetin as the flavonoid portion and rutinose as the sugar portion. Rutin was included as one of the original "vitamin P" substances because of its ability to decrease capillary permeability and fragility. Like quercetin, rutin is a biologically active flavonoid. It has been shown to have antiedemic, antiatherogenic, antiinflammatory and hypotensive properties.

Among the flavonoids, Quercetin is one of the most biologically active. Quercetin is the aglycone (non-carbohydrate portion of a glycoside molecule) of rutin, quercetin and other glycoside flavonoids. Quercetin is an especially potent antioxidant with some anti-inflammatory properties. It appears to stabilize the membranes of the mast cells that release histamine.

Quercetin has been shown to have an effect on a variety of biological systems, mostly through its interaction with calmodulin, a calcium regulating protein. One of the best studied effects of quercetin is its ability to prevent mast cells from de-granulating during an allergic response. In preventing mast cell de-granulation, quercetin prevents the release of histamine, one of the major triggers to the overall allergic response. Through similar actions, quercetin can act as an anti-inflammatory agent.

As a flavonoid, quercetin is able to stabilize membranes. This is not only true of free-floating blood cells, but also capillary and arterial walls. These activities are due to the ability of quercetin to act as a potent antioxidant as well as an inhibitor to the enzyme hyaluronidase (an enzyme that breaks down connective tissue). The benefits of quercetin are becoming well known, and purified quercetin should become more popular in years to come. The absorption of quercetin is limited, and studies have shown that the enzyme bromelain is capable of increasing the intestinal absorption of quercetin. Quercetin is listed in the National Formulary and can be purchased N.F.

Hesperidin is a molecule which contains hesperetin (a bioflavonoid molecule) and the disaccharide rutinose. It performs antioxidant actions as well as having potent anti-allergy, anti-inflammatory and anti-viral properties. It works with vitamin C for the promotion of vascular tissue strength. No longer considered a vitamin, Hesperidin and other bioflavonoids are now known to have many beneficial effects such as improving the effectiveness of vitamin C, improving capillary fragility, antioxidant and free radical protection to name but a few.