Controlled stand-alone matrix system for the controlled distribution of active substances (ab7 innovation s.a.s.u.) k gas station jobs


To be precise, this invention relates to a controlled matrix system for the distribution of active substances in a controlled quantity and solely at appropriate moments, for human and/or animal use, so that the substance released responds perfectly to an effectiveness requirement pre-defined and/or known depending on the intended target.

reservoir device for which the active substance in liquid solution is loaded into a reservoir. Said substance is diffused into the atmosphere either by migration through the semi-permeable polymer wall of said reservoir or by spraying in the form of droplets;

More particularly, the subject matter of this invention relates to a controlled stand-alone matrix system for the distribution at controlled speed and at precise appropriate moments of active substances incorporated into a polymer matrix. Said system comprises at least three essential components:

Devices comprising a hydrophobic polymer matrix for the distribution of active substances are also known. Said devices can in particular be in the form of bracelets, necklaces, tablets or any other form. Such devices only enable a continuous passive diffusion at ambient temperature of the active substances incorporated therein. This diffusion starts as soon as the pack is opened and cannot be stopped unless a new sealed pack is inserted, which requires the user to perform additional manipulations. The choice of formulation vectors of said active substances, that of the polymers for the matrix as well as the dimensions of the final device constitute the only way of controlling the release of these substances. Now, continuous diffusion is not always suitable for certain very specific treatments, for example when a localized diffusion of active substance is required solely at precise moments. Moreover, some polymer matrices that perform passive diffusion at ambient temperature sequester a considerable quantity, up to 50% by weight, of active substance at the end of its presumed use. In fact, the Applicant has observed that some non-volatile or low-volatile active molecules remain sequestered in the matrix, however, despite their optimal formulation by means of good vectors. Furthermore, some medical devices require that only part of the full release potential is used in order to be sure to use a kinetics zone where the dose is constant and at a level above the threshold of effectiveness. This operating mode entails a considerable waste of active substances and, on disposal, these devices still contain some of their active substances.

Although the Applicant has already developed passive-diffusion polymer-matrix devices in the form of tablets or bracelets, as described in patents FR2901096, FR2951645 and FR2959396, no known device based on a polymer matrix allows any type of active substance to be delivered at a controlled speed solely at precise appropriate moments. Moreover, no known matrix device is capable of releasing the active substances at a controlled speed so that the released quantity perfectly meets an effectiveness requirement pre-defined and/or known.

In order to improve the operation of passive-diffusion matrix devices, other components have been added so that the assembly constitutes a system. Some of the added components include plate- or heating-resistor heating elements applied to the polymer matrix. In this regard, the prior art is divided into two clearly distinct categories of matrix system: