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Resveratrol, a polyphenol found primarily in grapes, berries, and nuts, has been found to have powerful anti-cancer properties without being toxic to normal cells. While resveratrol is a phytoestrogen, it exerts chemopreventive effects through multiple pathways — it can inhibit the growth of both hormone receptor positive ( ER+/PR+) and hormone receptor negative ( ER-/PR-) breast cancer cells. list of electricity usage by appliances Resveratrol can prevent silencing of the BRCA1 gene, a gene that protects against breast cancer through its role in repairing DNA damage.

Resveratrol has also been shown to increase the effectiveness of a variety of breast cancer treatments. For example, resveratrol has been shown to potentiate the effects of several chemotherapy drugs ( Adriamycin, Alkeran, cisplatin, Taxol and Taxotere), the epidermal growth factor receptor ( EGFR) inhibitor Iressa, tamoxifen, and radiation treatment. Now a new study has helped explain the mechanism of action by which resveratrol enhances the treatment effects of Taxol (paclitaxel) in estrogen receptor positive (ER+) breast cancer cells.

We urge those undergoing chemotherapy to consume foods such as red grapes, blueberries and cranberries to obtain resveratrol rather than consuming it in supplement form. Safe and effective dosages of resveratrol have not been established. gas variables pogil worksheet answers Taking it in concentrated form separate from the other nutrients found in foods could have unintended adverse effects. For example, one study reported that resveratrol alone promoted mammary tumor growth and metastasis in a mouse model of estrogen receptor negative (ER-) breast cancer whereas it inhibited it in combination with other grape polyphenols. Another study reported that supplementation with resveratrol plus zinc in a rat model of breast cancer significantly increased the rate of development and number of carcinogen-induced mammary tumors.

The best food sources of resveratrol for breast cancer patients and survivors are red grapes and grape juice, blueberries and cranberries. electricity wiki Other potentially beneficial foods with significant levels of resveratrol include strawberries and pistachio nuts. Blackberries and raspberries also contain some resveratrol. gaston y daniela While red wine is an abundant source of resveratrol, its alcohol content makes it on balance harmful. Latest research show how resveratrol potentiates Taxol in ER+ cells

While neuroglobin is an oxygen binding protein expressed primarily in the nervous system, it also has a role in breast cancer estrogen signaling. A signaling pathway consists of a set of molecules that participate in a cascade of chemical reactions that together control cellular processes such as cell division or programmed cell death (apoptosis). In some cases, such as estrogen signaling pathways, a pathway can be initiated when a molecule, such as a hormone, attaches to a receptor on the cell membrane. Cellular levels of neuroglobin, which has a role in preventing apoptosis, are increased (upregulated) by the estrogen 17β‐estradiol ( E2). q gas station cleveland ohio As such, neuroglobin is part of an E2/estrogen receptor alpha (ERα) pathway which serves to prevent cancer cell death in presence of stressors such as chemotherapy drugs.

In the study, the authors investigated the possibility that resveratrol could increase the susceptibility of breast cancer cells to Taxol by influencing the E2/ERα/neuroglobin pathway. Resveratrol was found to reduce neuroglobin levels in ERα‐positive (MCF‐7 and T47D), but not in ERα‐negative (MDA‐MB 231) or in ERα and ERβ positive (SK‐N‐BE) breast cancer cells. Resveratrol reduced neuroglobin levels by interfering with both E2/ERα‐induced neuroglobin upregulation and E2‐induced ERα and protein kinase B (Akt) phosphorylation (which is involved in the induction of autophagy, another form of cell death). Although treatment with resveratrol did not appear to reduce breast cancer cell viability directly, it increased Taxol’s proapoptotic effects. gas vs electric oven for baking cakes The authors note that the findings demonstrate for the first time how resveratrol impairs the E2/ERα/neuroglobin signaling pathway and increases ERα breast cancer cell susceptibility to a chemotherapeutic agent.

Selected breast cancer studies The in vitro radiosensitizer potential of resveratrol on MCF-7 breast cancer cells Combination Therapy using Co-encapsulated Resveratrol and Paclitaxel in Liposomes for Drug Resistance Reversal in Breast Cancer Cells in vivo Resveratrol improves the anticancer effects of Doxorubicin in vitro and in vivo models Resveratrol, a polyphenol phytoalexin, protects against doxorubicin-induced cardiotoxicity Resveratrol Augments Paclitaxel Treatment in MDA-MB-231 and Paclitaxel-resistant MDA-MB-231 Breast Cancer Cells Resveratrol Sensitizes Tamoxifen in Antiestrogen-Resistant Breast Cancer Cells with Epithelial-Mesenchymal Transition Features Proteomic Profiling Reveals That Resveratrol Inhibits HSP27 Expression and Sensitizes Breast Cancer Cells to Doxorubicin Therapy Dietary grape polyphenol resveratrol increases mammary tumor growth and metastasis in immunocompromised mice Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer The effect of dietary zinc – and polyphenols intake on DMBA-induced mammary tumorigenesis in rats Resveratrol enhances the cytotoxic profile of docetaxel and doxorubicin in solid tumour cell lines in vitro