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If you test positive for an abnormal BRCA1, BRCA2, or PALB2 gene and you have never had breast cancer, you now know that you are at much higher-than-average risk of developing it over the course of your lifetime. The average lifetime risk of breast cancer for women is about 12%. For electricity 1 7 pdf women who have a BRCA1 or BRCA2 mutation, the risk of developing breast cancer in your lifetime is between about 69% and 72% — about 6 times greater than that of a woman who does not have the mutation. Your lifetime risk of ovarian cancer is significantly elevated as well: 17% to 44%, versus just under 2% for the general population. Men with BRCA abnormalities are considered to have a higher lifetime risk of male breast cancer, especially if the BRCA2 gene is affected. One study found that men with a BRCA2 mutation have a 7% lifetime risk of developing breast cancer. They are also at increased risk of developing prostate cancer.

While rare, it is possible for a person to have one BRCA1 and one BRCA2 mutation. Usually, this occurs in someone with Ashkenazi Jewish ancestry, due to the higher carrier frequency. For someone testing positive for both mutations, screening and risk reduction recommendations are the same as they would be for a person who tests positive for just electricity and magnetism equations one of these mutations. In a person who tests positive for both, the risk of passing each mutation to a child is 50%.

• Breast cancers in women with BRCA1 abnormalities are more likely to be estrogen-receptor-negative — meaning that the cancer’s growth is not fueled by the hormone estrogen — and to have high-grade cell growth. Both of these characteristics mean that chemotherapy will be more effective than hormonal (anti-estrogen) therapy in treating these cancers.

• BRCA1- and BRCA2-related cancers often test negative for overexpression of the gene known as HER2/neu. This genetic abnormality is not inherited, as BRCA1 and BRCA2 mutations are, but can develop in women over time. When the HER2 gene is overexpressed, the cancer cells have too many HER2 receptors (human electricity questions for class 10 epidermal growth factor receptor). HER2 receptors receive signals that stimulate the growth of breast cancer cells. HER2-positive breast cancer is considered to be a more aggressive form of the disease, but it can be treated with Herceptin (chemical name: trastuzumab), and other medicines that target the HER2 receptors. Most BRCA1- and BRCA2-related cancers cannot be treated with anti-HER2 treatments because they are HER2-negative.

If you have a breast cancer gene abnormality and you develop breast cancer, your doctor will work with you to determine how your BRCA status might affect your treatment decisions. For example, if you have a BRCA1 mutation, the breast cancer is less likely to be estrogen-receptor-positive, which means that you may not gas unlimited houston texas be a candidate for treatment with hormonal therapy. If you have a BRCA2 mutation, however, you are more likely to be a candidate for hormonal therapy. Because research on the PALB2 gene is ongoing, it’s not clear yet if cancers caused by a PALB2 mutation are likely to have specific characteristics.

You’ll also want to talk with your doctor about reducing the risk of a new, second breast cancer or ovarian cancer. Women with breast cancer and a BRCA1 or BRCA2 abnormality have a significantly greater risk of developing a new, second breast cancer, as well as ovarian cancer. If you want to lower your risk of a future breast cancer or ovarian cancer

• Preventive or prophylactic mastectomy, or removal of both breasts, has been found to reduce the risk of breast cancer in high-risk women by about 90%. After a diagnosis of one breast cancer in a woman with a genetic abnormality, the risk of her getting a new breast cancer is approximately 3% every year (for example, 15% over 5 years). Without a BRCA1 or BRCA2 mutation, the risk of developing a new breast cancer after one episode of breast cancer is only 1% per year.

• Preventive or prophylactic salpingo-oophorectomy, or removal of both ovaries and fallopian tubes, can reduce breast cancer risk by as much as 50% when it is done before menopause, because it takes away the body’s main source of the hormone estrogen. It also can greatly reduce ovarian cancer risk. The timing gas stoichiometry worksheet answers of removing the ovaries differs depending on whether a person has a BRCA1 or BRCA2 abnormality. For those with a BRCA1 abnormality, the recommended timing of removing both ovaries and fallopian tubes is between ages 35 and 40. For those with a BRCA2 abnormality, removing ovaries and fallopian tubes can be considered between ages 40 and 45.

• Aromasin (chemical name: exemestane), an aromatase inhibitor, has been shown to reduce the risk of first-time hormone-receptor-positive breast cancer in postmenopausal women at high risk. Aromasin isn’t approved by the FDA for this use, but doctors may consider it a good alternative to tamoxifen or Evista. In 2013, the American Society of Clinical Oncology (ASCO) released new guidelines on using hormonal therapy medicines to reduce breast cancer risk in high-risk women. These guidelines recommend that doctors talk to high-risk postmenopausal women about using Aromasin to reduce risk. ASCO is a national organization of oncologists and other cancer care providers. ASCO electricity powerpoint template guidelines give doctors recommendations for treatments that are supported by much credible research and experience. Visit the Aromasin page for more information.

• Arimidex (chemical name: anastrozole), also an aromatase inhibitor gas zeta costa rica, has been shown to reduce the risk of first-time hormone-receptor-positive breast cancer in postmenopausal women at high risk. Like Aromasin, Arimidex isn’t approved by the FDA for this use, but doctors may consider it a good alternative to tamoxifen, Evista, or Aromasin. Visit the Arimidex page for more information.

• Begin annual breast MRI at age 25 or mammogram if breast MRI is unavailable. Screening may start sooner if a family member has been diagnosed under the age of 30. Between ages 30 and 75, begin annual mammogram and breast MRI. For women over the age of 75, screening should be considered on an individual basis with their physicians. Men should receive yearly clinical breast exam starting at age 35, and they should start performing breast self-exam at age 35. Consider participating in a clinical trial evaluating newer methods of early detection.