Linzess gas tax by state

########

Linzess (linaclotide) is a new prescription drug which can be used to treat both irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults. It is the first treatment available in a new class of medications called GC-C agonists. It received FDA approval in the USA on 30 August 30 2012 and became available in pharmacies in December 2012. It is designed to relieve abdominal pain and constipation associated with IBS-C and constipation and hard stools associated with CIC. How effective is Linzess in clinical trials?

So I am a 23 year-old female and right around when I graduated college I started to notice something different in my digestive pattern. Truth is, my constipation started around sophomore year in college, but I began to pay attention to it at the end of my senior year because I was attributing the constipation to the never-ending stress that my education was giving me.

I made it through and went to bed that night thanking God that he had given me the strength to get through the day because in truth, I have never experienced something so painful before. So there I was the next day, waking up and ready to go about my business when around 4pm I was hit with the same insufferable pain and diarrhea and screaming for someone to take the pain away.

My Dad ended up driving me to the hospital and I was given a dose of morphine, Demerol and Dilaudid all at the same time because of the amount of pain I was in. I think the nurse told me it was equivalent to around 11mg of morphine, which is quite an intense amount of opioids in the human body. electricity vs gasoline Needless to say I was very drugged and vomiting from the nausea the pain medication had caused, but I was so very grateful that the pain had gone.

There I was again rushing to the hospital, running red lights and praying to God to end the pain. I was again admitted to the ED and given pain medication and I stayed in a drugged-up state so grateful for the relief while the doctors were scratching their heads wondering what was going on with me. I had every test done to me and they all came back normal…so they sent me home again saying it was a side effect of Linzess.

The diarrhea came and unsurprisingly I was being whisked off to the ED, where I now knew the staff by name and they all knew the routine of my admittance. I was given a cocktail of pain meds again and the doctors said they were going to admit me for further observation. r gasquet Finally, I could feel a little bit of relief that I had support 24/7 now if I were to have a pain spell again.

The next day in the hospital all of the doctors rounded on me, basically saying they didn’t know what was wrong and that I had a really bad reaction. I was put on a liquid diet and mind you, I had already not being eating because of the pain. I was nothing short of absolutely miserable. I was starving, hopeless and afraid of doing anything.

I ended up being discharged the next day because my pain had somewhat stopped and I just wanted my own bed. Overall I ended up losing seven pounds and my mental health has suffered immensely from this drug. I am afraid to eat or drink and with any slight discomfort in my lower digestive tract I can start to feel my heart race. I no doubt have some type of acute stress disorder because I can only bring myself to talk about this ordeal four months after this incident.

And even as my heart rate is pulsating as I’m writing this, I am hoping that someone can benefit from my experience. If you or someone you know is about to start Linzess, please think about it carefully. Have your doctor tell you every risk and every benefit. Yes, this drug has worked miracles for some people, but also this drug has ruined my life in a way.

I know that I do have a redundant sigmoid which is most likely the root of my condition. I also was tested for dyssynergic defecation disorder and pelvic floor disorder. To make things even more complicated I have lost 45lbs in the last year or so. I was told by one specialist that I may have damaged the mucous lining of my colon, which is where nutrient absorbtion occurs.

I have been taking Linzess for a year now. It’s amazing. electricity and magnetism study guide 5th grade I had gastric bypass and severe constipation with impactions with a history of IBS-C. The first time I tried this medicine I hated it. It was like my rectum was an unpredictable volcano! So I stopped it. By my second ER visit for impactions, I tried it again and now I can’t live without it.

I told the doctor that the only way I go is with help from Metamucil, tea, Dulcolax, Activia yogurt and a Fiber One bar every day! If I do not do this the pain in my back and stomach is just unbearable. As for my review on Linzess – I still haven’t gone to the bathroom. I feel nausea, bloating and I’m getting discouraged. gas station car wash All I wanna do is go! Do I give this a little longer? I’m seriously frustrated.

I have had IBS-C for decades and was given Linzess by my MD. I took it as directed and it was a disaster. I would describe it as cholera in a bottle. The diarrhea started unannounced, was explosive and lasted 10 hours after ingestion. I called my doctor’s office and the nurse said this was normal, would abate in time and wasn’t an abnormal reaction. I persevered for a week before I quit. I can’t imagine ever trying this drug again. The experience was awful.

After reading several of the reviews of Linzess I can tell you that my experience on this new medication has been nothing short of amazing. I was diagnosed with IBS with constipation in November 2009 and following many excruciating trials of over-the-counter remedies I visited my gastroenterologist who prescribed Amitiza initially. gas after eating dairy Although I took a modified dose of the drug due to its rather harsh side effects it worked fairly effectively for the next four and a half years and then suddenly stopped working.

Thankfully Linzess was available and so I began taking it about six months ago, once per day approximately 30 minutes before breakfast (145mcg) and within 20 minutes following the morning meal it works like a charm. The only caveat is that I need to be close to a bathroom for up to 30 minutes as I continue to have episodes of diarrhea. The fact that I only have to take this medication once daily is a blessing…

It was when I got off the Align for about a week and tried dosing Linzess for 12 straight days that I had a savage attack of abdominal pain (trapped gas and splenic flexure syndrome). I had never taken Linzess for more than three or four days in a row prior to the 12-day stint. I got back on Align immediately, discontinued Linzess for a few days and in four or five days the trapped gas abated.

My conclusion is that Linzess is a very potent and effective laxative, perhaps to be taken every second or third day but not without the Align buffer. On its own, taken day after day, my experience suggests that Linzess may actually contribute to abdominal discomfort and bloating rather than alleviate it. I realize that this will vary from individual to individual, but I just wanted to share my own experience. Word of caution: you may experience thunderous diarrhea with Linzess, often after an initial somewhat firm stool. It’s like milk of magnesia to the tenth power.

I have suffered from IBS-C for 30+ years. I eat heathily and exercise regularly. I am not overweight. electricity drinking game I could never understand why I have IBS-C. My gastroenterologist recommended Linzess and I took it as directed. Within 45 minutes I felt a warmth spread in my upper sternum, a definite pressure, a feeling of fullness, sweating and nausea. I also got a little short of breath but that may be due to the anxiety I was feeling because I thought I was having a cardiac event.

I called the gastroenterologist on call and he said he had been prescribing Linzess for about two months and none of his 17 patients reported experiencing any side effects. He instructed me to go to the ER if my symptoms did not resolve in the next hour just to rule out a cardiac event. I had had a complete physical with a cardiac work-up two months prior so that was ruled out. I began to feel better after 30 minutes when my discomfort peaked so I had a total of two hours of discomfort. I also take Prilosec so it was not GERD. I will never take this med again.

I have been on Linzess with amitriptyline for about a month and a half and I have noticed that I feel horrible from constipation, cramping and nausea if I don’t take it at all. grade 6 electricity unit test However if I take it as prescribed, before I eat first thing in the morning, I feel sick all day! It only took me two times of doing that before I figured out that it was the Linzess. So, as long as I take it at night before I go to bed, with the amitripyline, I am better.

Yes, Zelnorm is off the market, but three months ago I was given this new drug that was approved by the FDA in the United States called Linzess. I was on Zelnorm for years (even after they took it off the market in the US) and it was a miracle pill. I have only 18 inches of colon left and I had suffered from horrible constipation. None of my doctors could figure out why I have constipation instead of diarrhea – they still can’t figure it out and it is 12 years since my surgery.