Oral, gastric bugs may help pinpoint stomach cancer iuk med online astrid y gaston lima menu english

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The authors found a significant abundance of five species: Peptostreptococcus stomatis, Parvimonas micra, Streptococcus anginosus, Slackia exigua, and Dialister pneumosintes. The first two are oral bacteria, and may have important roles in GC progression, they wrote in Gut.

“We observed significantly higher abundance of oral bacteria in GC than in all other benign stages,” Yu’s group wrote, calling for more epidemiological studies and the development of biofunctional assays to clarify the cause and effect nexus.

“In this study, we observed significant microbiome dysbiosis along different stages of gastric tumourigenesis, with significant enrichments of oral bacterial taxa forming niche-specific interactions that became increasingly stronger towards carcinogenesis,” they stated.

“However, the potential clinical implication of these findings for the future is that if microbial differences were to appear early in the disease process in areas that could be tested easily, say with an oral swab or a breath or stool test, then we could have an early biomarker of progression from early to advanced cancer,” added Moss, who was not involved in the study.

Hohhot, the capital of Inner Mongolia in northern China, has a population of 2.87 million, consisting of 88.4% Han Chinese and 8.56% Mongolians. This population typically consumes meats, especially lamb, but also dairy products such as milk, yogurt, and cheese.

Yu’s group performed 16S rRNA gene analysis on 81 gastric mucosal from Xi’an and independently validated the results in samples of 126 cases from Hohhot. “We observed significant mucosa microbial dysbiosis in intestinal metaplasia and gastric cancer subjects, with significant enrichment of 21 and depletion of 10 bacterial taxa in GC compared with superficial gastritis (q<0.05),” they wrote.

In the X’iany cohort, the five GC-enriched bacterial taxa distinguished GC from SG with an area under the receiving operator characteristic curve (ROC AUC) of 0.82. In addition, microbial network analysis showed increasing correlation strengths among them with disease progression ( P<0.001). The findings were confirmed in the Hohot cohort, with the five bacterial markers distinguishing GC from SG with a similar ROC AUC of 0.81.

The authors found a significant abundance of five species: Peptostreptococcus stomatis, Parvimonas micra, Streptococcus anginosus, Slackia exigua, and Dialister pneumosintes. The first two are oral bacteria, and may have important roles in GC progression, they wrote in Gut.

"We observed significantly higher abundance of oral bacteria in GC than in all other benign stages," Yu’s group wrote, calling for more epidemiological studies and the development of biofunctional assays to clarify the cause and effect nexus.

"In this study, we observed significant microbiome dysbiosis along different stages of gastric tumourigenesis, with significant enrichments of oral bacterial taxa forming niche-specific interactions that became increasingly stronger towards carcinogenesis," they stated.

"However, the potential clinical implication of these findings for the future is that if microbial differences were to appear early in the disease process in areas that could be tested easily, say with an oral swab or a breath or stool test, then we could have an early biomarker of progression from early to advanced cancer," added Moss, who was not involved in the study.

Hohhot, the capital of Inner Mongolia in northern China, has a population of 2.87 million, consisting of 88.4% Han Chinese and 8.56% Mongolians. This population typically consumes meats, especially lamb, but also dairy products such as milk, yogurt, and cheese.

Yu’s group performed 16S rRNA gene analysis on 81 gastric mucosal from Xi’an and independently validated the results in samples of 126 cases from Hohhot. "We observed significant mucosa microbial dysbiosis in intestinal metaplasia and gastric cancer subjects, with significant enrichment of 21 and depletion of 10 bacterial taxa in GC compared with superficial gastritis (q<0.05)," they wrote.

In the X’iany cohort, the five GC-enriched bacterial taxa distinguished GC from SG with an area under the receiving operator characteristic curve (ROC AUC) of 0.82. In addition, microbial network analysis showed increasing correlation strengths among them with disease progression ( P<0.001). The findings were confirmed in the Hohot cohort, with the five bacterial markers distinguishing GC from SG with a similar ROC AUC of 0.81.