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Dr. Alessandro Sette has devoted more than 30 years of study towards understanding the immune response, measuring immune activity, and developing disease intervention strategies against cancer, autoimmunity, allergy, and infectious diseases. gas variables pogil answers The laboratory is defining in chemical terms the specific structures (epitopes) that the immune system recognizes, and uses this knowledge to measure and understand immune responses.

The Sette lab’s approach uses epitopes as specific probes to define the immune signatures associated with productive/protective immunity versus deficient immunity/immunopathology. This research will improve understanding of how the body successfully battles infection, and conversely, how pathogens escape the immune system, causing the individual to succumb to disease. Because of the laboratory’s success in its study of immune response, Sette and his team believe their research will lead to development of new therapeutic and prophylactic approaches to fighting infectious diseases. electricity storage association In this area, Sette’s disease focus has shifted over the years from HIV, HBV and HCV to emerging diseases and diseases of potential biodefense concern to, most recently, diseases and pathogens relevant to worldwide global health, including dengue viruses, malaria, tuberculosis, and trypanosome infections.

Furthermore, Dr. Sette’s team has adapted the methods and techniques developed in the context of infectious disease to understand the T cell response to common allergens. These efforts have resulted in the discovery of previously unknown human T cell epitopes that may be key in the initiation of allergic responses, and to the development of biochemical and bioinformatic tools that have been used to map the human T cell response to a large panel of common allergens.

Finally, Dr. electricity and magnetism worksheets 4th grade Sette has overseen the design and curation efforts of the national Immune Epitope Database (IEDB), a freely available, widely used bioinformatics resource, since its inception in the early 2000s. The IEDB catalogs all epitopes for humans, non-human primates, rodents, and other vertebrates, from allergens, infectious diseases, autoantigens and transplants, and includes epitope prediction tools to accelerate immunology research around the world.

Dr. Sette is currently a Member and Head of LJI’s Division of Vaccine Discovery as well as chair of the Institute’s Center for Infectious Diseases. Dr. Sette has a doctorate in Biological Sciences from the University of Rome and did postdoctoral work at the National Jewish Center for Immunology and Respiratory Medicine in Denver, Colorado. static electricity vocabulary words In 1988, Dr. electricity prices per kwh 2013 Sette joined Howard Grey, M.D. at the newly founded Cytel, in La Jolla, and was also appointed as an adjunct assistant professor at The Scripps Research Institute. He founded Epimmune in 1997, where he served both as Vice President of Research and Chief Scientific Officer until 2002, when he joined LJI.

Dr Sette is a leader in the field of T cell epitope-MHC interactions, beginning with his contribution to the discovery of the biological function of MHC in the mid 80s to mid 90s. From those studies he and his collaborators further developed the notion that different MHCs have distinct binding specificities that can be used to predict epitopes. astrid y gaston lima menu english The Sette group also discovered and characterized how MHC variants can be grouped according to broad common functional specificities (MHC supertypes), greatly facilitating epitope classification, characterization and understanding the basic rules of epitope-MHC interactions. At the same time, several studies have outlined the fine specificity of different closely related alleles, in some cases clearly associated with predisposition to disease resistance or susceptibility.

As senior project manager for the Sette and Peters laboratories, I draw on more than seven years of experience managing large, multi-subcontractor grants and research projects in academia and industry. Currently, I keep on track a number of different research programs (including allergy, infectious disease, and Parkinson’s disease) and oversee several large contracts and grants from NIH and commercial companies.

I received a BS degree in Applied Chemistry from Harvey Mudd College in Claremont, CA, and a PhD in Chemistry (Biophysics) from the University of Virginia in 2003. After a two-year stint as a postdoctoral research fellow in Pharmacology in the laboratory of Dawn Quelle at the University of Iowa, where I studied the molecular mechanisms of tumorigenesis, I made the switch to industry. I moved to Vancouver, BC, Canada to join the biophysical characterization department of Celator Pharmaceuticals (a spin-off company from the BC Cancer Agency) as a research scientist before my next position took me to York, England. There, I held a dual position as a Commercial Operations Manager and Research Scientist at Pro-Cure Therapeutics before I returned to the U.S. in 2012 to join the La Jolla Institute.

The recent increase in cases of whooping cough among teenagers in the US suggests that the protection conferred by the acellular Bordetella pertussis vaccine (aP) that became standard in the mid 1990s is of shorter duration than that conferred by the whole-bacteria formulation (wP) used since the 1950s. To understand the potential basis for this differential efficacy, we are comparing epitope repertoires and exploring the molecular basis for differences in T cell responses between aP- and wP-primed individuals.

Allergy seasonality: In a large effort supported by a consortium grant from NIAID, the Sette group is collaborating with the Peters and Vijayanand labs to test the hypothesis that different stages (in-season versus out-of-season), types (rhinitis versus asthma), and severities of allergic disease are associated with not only differential magnitude of T cell responses, but also distinctive patterns in terms of the T cell subsets involved and their interactions. This work focuses on three important allergens, namely timothy grass), house dust mite (HDM), and cat dander. One set of these studies is characterizing responses in moderate/severe and mild asthmatics, and contrast them with those observed in non-asthmatic individuals suffering from allergic rhinitis. gas utility bill To examine the effect of seasonality, we are comparing T cell responses both in- and out-of-season between allergic and non-allergic individuals.