U.va. researcher receives $1 million grant to develop new method for determining biological structures the cavalier daily gas efficient cars 2010


Early January, Wiener won a $1 million grant from the William M. Keck Foundation to use distances within a protein to map its structure. This new method promises to be cheaper, faster and easier than traditional techniques. Wiener was the University’s nominee for the Keck Foundation Grant in the Medical Science category. The press release announcing this award was published Feb. 15.

The Keck Foundation is an independent philanthropic organization based in Southern electricity and magnetism physics definition California and is famous to researchers for funding “high-risk, high-reward” scientific projects. According to Joel Baumgart — the senior research program officer in the Office of the Vice President for Research — most research grants in the University are gas variables pogil worksheet answers funded by federal agencies such as the National Institutes of Health. However, these agencies tend to give money to research that already has a lot of preliminary data and is the next logical step in that researcher’s work.

Although Wiener is the first researcher from the University’s School of Medicine to receive a Keck Foundation grant, in 2016 University biologist Eyleen O’Rourke was awarded $1.2 million from z gas el salvador the same foundation. Baumgart credits some of these recent funding acquisitions to the expansion of the University’s corporate and foundations relations office.

A focus of Wiener’s research is preparing numerous, lower-resolution samples of proteins — rather than risky and time-consuming samples — to solve the shape of a molecule. Wiener explained that determining the shape of a molecule is like creating an image. One method is taking a picture of the the whole — which in the submicroscopic realm is expensive and kansas gas service bill pay often does not work — and another method is finding distances between the parts of the whole and using those distances to create an image.

Other methods used to solve protein structures are x-ray crystallography, in which a crystallized protein sample is exposed to x-ray beams, as well as cryo-electron microscopy, which cools samples to extremely low temperatures and studies them with an electron microscope. Wiener’s proposed method — called serial solution scattering structure determination, or S4D — uses a large number of samples with chemical labels that are analyzed with x-rays and computational methods to determine the structure of a protein.

Another aspect of S4D is the possibility of determining structures in a cell-like environment. Lukas Tamm, chairman of the Molecular Physiology and Biological Physics department in the University’s Medical School electricity worksheets high school, explained that proteins, especially ones embedded in the membrane of a cell, are notoriously difficult to map because other components are attached to them. Once isolated for study, the protein is no longer in its natural system.

The next immediate steps for Wiener’s research are preparing the samples using small proteins called peptides and adding labeling agents to them. Sample preparation will occur in Wiener’s lab — in the University’s Fontaine Research Park — and in the next few months the researchers will take the labelled proteins to the electricity vs gasoline Department of Energy’s National Synchrotron Light Source gas variables pogil worksheet answer key II, a facility in the Brookhaven National Laboratory in New York that houses beamlines that will analyze the sample and provide necessary data to evaluate Wiener’s method.

“Molecules are three-dimensional — they move [and] breathe,” Goblirsch said. “Ultimately we want to know the three-dimensional architecture so one way is to … get lots of these distances, but then somebody has to develop software and the algorithms and the know-how to feed that into a three-dimensional model that takes advantage of all those distances.”

Baumgart explained that federal grants for research provide an additional 61 percent of the amount of each grant to the University to pay for general facilities, such as electricity and WiFi. Grants from foundations such electricity and magnetism review sheet as the Keck do not pay the extra 61 percent, and because of this, the University in the past tended not to encourage applications for foundation grants. However, Baumgart suggests that after obtaining a large grant from a foundation, more federal grants tend to follow.